Kairos Pharma (NYSE American: KAPA), a clinical-stage biopharmaceutical company, has published a peer-reviewed study highlighting a potential breakthrough in addressing drug resistance to EGFR-targeted therapies for non-small cell lung cancer (NSCLC). The study, published in Drug Resistance Updates, identifies CD105 (endoglin) as a key factor in mediating resistance to osimertinib, a frontline treatment for EGFR-mutant NSCLC. Preclinical models demonstrated that targeting CD105 with ENV105 (carotuximab), a CD105-neutralizing antibody, restored treatment sensitivity, suggesting a novel combination therapy strategy to overcome drug resistance. Kairos Pharma is currently evaluating this approach in clinical trials.
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About Kairos Pharma Ltd.
Based in Los Angeles, California, Kairos Pharma is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Its lead candidate, ENV105, is an antibody that targets CD105—a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate resistant prostate cancer and a Phase 1 trial for lung cancer, addressing significant unmet medical needs. For more information, visit the company’s website at www.KairosPharma.com.
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