Kairos Pharma (NYSE American: KAPA) presented preclinical data on its GITR agonist, KROS 101, during the plenary session of the AACR-JCA conference. The study demonstrated that KROS 101 enhances T cell infiltration, proliferation, and tumor-killing ability in melanoma and glioblastoma models while reducing regulatory T-cell suppression. Compared to the GITR antibody TRX518, KROS 101 showed superior tumor reduction in a human GITR knock-in mouse model. The company sees potential for the therapy to expand T cell responses and improve cancer treatment, supporting further clinical development.
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About Kairos Pharma Ltd.
Based in Los Angeles, California, Kairos Pharma is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Its lead candidate, ENV105, is an antibody that targets CD105—a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate resistant prostate cancer and a Phase 1 trial for lung cancer, addressing significant unmet medical needs. For more information, visit the company’s website at www.KairosPharma.com.
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